Effect of Blood Flow Restriction Resistance Exercise on Functional Mobility in Pre-Frail Older Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- National Cheng Kung University
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Change of 30 seconds sit to stand
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study investigates the effect of blood flow restriction with resistance exercise on functional mobility in pre-frail older adults. It is hypothesized that receiving resistance exercise with blood flow restriction will exhibit better improvement on functional mobility than only receiving resistance exercise in pre-frail older adults.
Detailed Description
Participants aged over 65 years old with less than two items positive of Fried frailty phenotype assessment result will be recruited. The participants will be randomly assigned to two training groups, blood flow restriction resistance exercise and traditional resistance exercise. Both groups will receive the training 30 minutes/session, two sessions/week for six weeks. Muscle strength of the lower extremities and functional mobility tests will be used to assess outcomes at pre-training, 3-week after training, post-training, and one-month and two-month follow-up.
Investigators
Pei-Yun Lee
Associate professor
National Cheng Kung University
Eligibility Criteria
Inclusion Criteria
- •Aged over 65 years old
- •Fried frailty index fulfill 1-2 criteria
- •Able to walk 6 meters independently
- •Able to understand and follow ≥ 3 instructions
Exclusion Criteria
- •Severe hypertension (\>180/110mmHg)
- •Peripheral neuropathy
- •History of deep-vein thrombosis (DVT)
- •Cardiovascular diseases (i.e. Heart failure NYHA Classification III or IV, myocardial infarction, pulmonary hypertension, coronary artery stenosis)
- •Neuromuscular diseases (i.e. Stroke, Parkinsons' disease)
- •History of resisted exercise training program within the last 6 months before screening
Outcomes
Primary Outcomes
Change of 30 seconds sit to stand
Time Frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
30 seconds sit to stand test
Change of muscle strength of the lower extremities
Time Frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Muscle strength of bilateral hip flexors, knee extensors, ankle dorsiflexors and plantarflexors
Change of Timed-Up and Go (TUG) test
Time Frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Timed-Up and Go test
Secondary Outcomes
- Change of muscle mass(Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention)
- Change of one-repetition maximum(Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention)
- Change of hand grip strength(Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention)