Effect of Blood Flow Restriction Resistance Exercise on Functional Mobility in Pre-Frail Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Change of 30 seconds sit to stand
研究概览
简要总结
This study investigates the effect of blood flow restriction with resistance exercise on functional mobility in pre-frail older adults. It is hypothesized that receiving resistance exercise with blood flow restriction will exhibit better improvement on functional mobility than only receiving resistance exercise in pre-frail older adults.
详细描述
Participants aged over 65 years old with less than two items positive of Fried frailty phenotype assessment result will be recruited. The participants will be randomly assigned to two training groups, blood flow restriction resistance exercise and traditional resistance exercise. Both groups will receive the training 30 minutes/session, two sessions/week for six weeks. Muscle strength of the lower extremities and functional mobility tests will be used to assess outcomes at pre-training, 3-week after training, post-training, and one-month and two-month follow-up.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 95 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged over 65 years old
- •Fried frailty index fulfill 1-2 criteria
- •Able to walk 6 meters independently
- •Able to understand and follow ≥ 3 instructions
排除标准
- •Severe hypertension (>180/110mmHg)
- •Peripheral neuropathy
- •History of deep-vein thrombosis (DVT)
- •Cardiovascular diseases (i.e. Heart failure NYHA Classification III or IV, myocardial infarction, pulmonary hypertension, coronary artery stenosis)
- •Neuromuscular diseases (i.e. Stroke, Parkinsons' disease)
- •History of resisted exercise training program within the last 6 months before screening
结局指标
主要结局
Change of 30 seconds sit to stand
时间窗: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
30 seconds sit to stand test
Change of muscle strength of the lower extremities
时间窗: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Muscle strength of bilateral hip flexors, knee extensors, ankle dorsiflexors and plantarflexors
Change of Timed-Up and Go (TUG) test
时间窗: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Timed-Up and Go test
次要结局
- Change of muscle mass(Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention)
- Change of one-repetition maximum(Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention)
- Change of hand grip strength(Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention)
研究者
Pei-Yun Lee
Associate professor
National Cheng Kung University