on-Invasive Electrocardiographic Imaging of Atrial Fibrosis Substrate in Patients with persistent Atrial Fibrillatio
Phase 4
- Conditions
- I48Atrial fibrillation and flutter
- Registration Number
- DRKS00014687
- Lead Sponsor
- niversitäts-Herzzentrum Freiburg-Bad Krozingen - Klinik für Kardiologie und Angiologie II
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 41
Inclusion Criteria
Patients age more or equal to 18 years for both sexes
- First catheter ablation procedure for symptomatic persistent AF
- Given and signed consent by the patient to participate to this study
Exclusion Criteria
- Paroxysmal or long persistent AF
- Pregnancy
- Specific exclusion criteria for MRI (Patients with following criteria will not undergo MRI, but can be included in the study for ECG-Imaging and catheter mapping of atrial Low Voltage Areas): Implanted Cardiac Devices (Pacemaker, ICD), Claustrophobia
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Spatial correlation between the distribution and extent of LVA (low voltage areas) and atrial regions of slow electrical conduction (due to increase fibrosis) on ECGI-Maps (the day before the procedure) and invasive atrial voltage maps (during the ablation)<br>
- Secondary Outcome Measures
Name Time Method - Spatial correlation between the distribution and extent of LVA and atrial regions of slow electrical conduction (due to increase fibrosis) on ECGI-Maps (the day before ablation) and loss of wall thickness and fat deposition at MRI (1-30 days before ablation).<br>- Predictive value of the extent of atrial low voltage substrate (assessed by ECGI vs invasive voltage mapping vs loss of wall thickness and fat deposition at MRI) on arrhythmia recurrence rate 12 months after the AF ablation. Arrhythmia recurrence is defined as AF or atrial tachycardia lasting > 30 seconds in 24-72 hour holter recordings at 6 and 12 months follow-up after the AF ablation procedure.<br>