Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) Therapy Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the Treatment of Post-Traumatic Stress Disorder: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 4
- 主要终点
- Remission rate at Week 6
研究概览
简要总结
This randomized controlled trial aims to compare the efficacy of Eye Movement Desensitization and Reprocessing (EMDR) therapy versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the treatment of Post-Traumatic Stress Disorder (PTSD). Adult patients diagnosed with PTSD will be randomly assigned to receive either EMDR therapy or SSRIs for a period of six weeks. The primary outcome is the rate of remission as measured by validated PTSD symptom severity scales at Week 6. Secondary outcomes include changes in functional impairment and patient-reported quality of life. The study seeks to determine whether EMDR therapy is a non-pharmacological alternative to SSRIs for achieving symptom remission in PTSD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-60 years
- •Clinical diagnosis of Post-Traumatic Stress Disorder (PTSD)
- •Duration of illness ≥ 6 months
- •Able to provide informed consent
排除标准
- •Current substance abuse or dependence
- •History of psychotic disorder or bipolar disorder
- •Active suicidal ideation
- •Concurrent psychotherapy or psychiatric medication (except study-assigned SSRI)
研究组 & 干预措施
EMDR Therapy
Participants will receive Eye Movement Desensitization and Reprocessing (EMDR) therapy over six weeks.
干预措施: Eye Movement Desensitization and Reprocessing Therapy (Behavioral)
Selective Serotonin Reuptake Inhibitors (SSRIs)Treatment
Participants will receive selective serotonin reuptake inhibitors (SSRIs) such as Sertraline over six weeks.
干预措施: Selective serotonin reuptake inhibitors (Drug)
结局指标
主要结局
Remission rate at Week 6
时间窗: 6 weeks
Each group's proportion of participants achieving remission from PTSD is defined as having a score below 22 on the PTSD Checklist for DSM-5 (PCL-5; range 0-80, where higher scores indicate worse PTSD symptoms), a validated PTSD scale.
次要结局
- Change in functional impairment score(6 weeks)
研究者
Asad Ullah Jan
Consultant Psychiatrist
Combined Military Hospital Nowshera