JPRN-jRCTs031210097已完成未知
A randomized, controlled trial of rifampicin for non-demented elderly with Alzheimer's disease neuropathology
Iwata Atsushi0 个研究点目标入组 15 人开始时间: 2021年5月18日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 15
研究概览
简要总结
The effects of treatment with rifampicin were studied in elderly patients with Alzheimer's disease pathology without dementia in twelve weeks.In the placebo group, there was no trend toward a decrease in CSF NfL, while in the control group, there was a trend toward a decrease, although it not statistical significant.ABeta oligomer and tau oligomer in the CSF also showed an increasing trend in the placebo group, while there was a decreasing trend in the control group, although it not statistical significant.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 65age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1) Written informed consent to the participation in this research has been provided
- •2) Men and women aged 65 or over at the time of obtaining informed consent
- •3) Person who has been determined to have the pathology of Alzheimer's disease based on amyloid Beta 42/40 and the concentration of p-tau181 in the
- •cerebrospinal fluid
排除标准
- •1) Person who has been judged to have dementia by CogState
- •2) Person who has been diagnosed with dementia in the last 5 years
- •3) Person with liver dysfunction with more than 3 times the upper limit of the normal range of ALT or AST
- •4) Person with renal dysfunction with less than 50 ml / min of eGFR
- •5) Person with a history of hypersensitivity to Rifampicin
- •6) Person who has taken Rifampicin within the last 4 weeks
- •7) Person whose inclusion in the research is deemed inappropriate by the principal investigator or sub-investigator
研究者
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