Pain Managment After VATS to Reduce Postoperative Pain and Improve Pulmonary Function
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Time to first rescue analgesia
研究概览
简要总结
Thoracic surgery is now common and as other surgeries evolution of minimally invasive techniques is employed. Video-assisted thoracic surgery (VATS) produces little scar but may produce severe pain that may affect the pulmonary function. Many procedure was developed like intercostal nerve block which require injections at multiple levels, Insertion of local anaesthetic (LA) in the surgical drain but that was dangerous due to the large amount of LA and not sufficient to completely eliminate pain. Bupvicaine nebulization, through surgical port which won't make any other wound, thought to be sufficient because Nebulization will enable us better distribution and less amounts of LA. Bupvicaine is local anaesthetic amide group that works by blocking sodium channels thus preventing progression of action potential.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients that reach American socity of anesthesiologist class 1-3
- •Scheduled for VATS surgery under general anesthesia.
排除标准
- •● Allergy to local anesthetics
- •Patient with pleural inflammation due to recent pneumonia
- •Patients who are unable or unwilling to perform spirometer test
- •Renal dysfunction: (Elevated creatinine > 2 mg\dl)
- •Hepatic dysfunction: (Elevated hepatic enzymes three times above normal value)
- •History of addiction
研究组 & 干预措施
Intrapleural bupivacine nebulization
Intrapleural nebulization of bupivacine (10 ml of bupivacaine 0.5%) + Intravenous normal saline as a placebo
干预措施: Intrapleural bupivacine nebulization (Drug)
Intravenous paracetamol and ketorolac
Intravenous analgesia: paracetamol (one gram) and Ketorolac (30 mg) + Intrapleural normal saline (10 ml) as a placebo
干预措施: Intravenous paracetamol and ketorolac (Drug)
结局指标
主要结局
Time to first rescue analgesia
时间窗: The first 24 hours postoperatively
次要结局
- Total opioid consumption(The first 24 hours postoperatively)
研究者
Essam El-den Moubark Mohammed Hussein
Resident doctor
Assiut University
