Acute and chronic cardiorespiratory changes in COVID-19 hospitalized patients: role of endothelial function and cardiovascular health in clinical-functional outcomes and effect of physical telerehabilitation

niversidade Estadual Paulista - UNESP0 个研究点开始时间: 2020年5月24日最近更新: 2023年5月29日

适应症

试验速览

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•At least 100 adult patients (aged over 18 years), of both sexes, diagnosed with COVID19 in molecular biology exam, admitted (intensive care unit or infirmary) to referral hospitals in the state of São Paulo will be evaluated. According to the phases of the study, and for inclusion, volunteers must: PHASE 1 (to assess endothelial function and functional capacity): present hemodynamic and respiratory stability; not having the need for emergency medical care; not to be at imminent risk of death. The inability to express consent to participate in the study will not be considered an exclusion criterion, however, in this case, the informed consent form must be signed by the legal guardian. PHASES 2 and 3: not being pregnant; not be lactating. Patients with decompensated cardiovascular and/or pulmonary disease, and/or pacemaker users, and/or who have absolute contraindications for physical exercise (acute myocardial infarction; unstabilized unstabilized angina; uncontrolled cardiac arrhythmias with repercussion will not be included) hemodynamic; symptomatic severe aortic stenosis; uncontrolled symptomatic heart failure; acute pulmonary embolism or pulmonary infarction; acute myocarditis or pericarditis; acute aortic dissection).

•Exclusion criteria will include: important hemodynamic and/or electrocardiographic changes during the cardiopulmonary stress test; need for hospital readmission; failure to meet 60% of scheduled interventions. Even if exclusion occurs during the phases, these patients will still be followed up by telephone, up to 12 months, to assess out-of-hospital outcomes.

发起方

niversidade Estadual Paulista - UNESP