Prevention of recurrent depression with psychotherapy, led by a primary care nurse.
- Conditions
- recurrent depression, primary care, preventive cognitive therapy, nurserecidiverende depressie, terugkerende depressie, huisartsenpraktijk, preventieve cognitieve therapie, praktijkondersteuner
- Registration Number
- NL-OMON28129
- Lead Sponsor
- niversity Medical CenterVrije Univeristeit Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 268
Inclusion Criteria
1. Age 18-65 year;
2. At least 2 confirmed previous MDD episodes with the SCID 42 in the last 5 years;
Exclusion Criteria
1. Current mania or hypomania or history of bipolar illness;
2. Any current organic or psychotic disorder;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome measure is the cumulative incidence of recurrences meeting DSM-IV criteria for a major depressive episode in both arms. Along to this pragmatic trial the cost-effectiveness is measured, defined from a societal perspective meaning that the costs of the intervention, health care uptake, patients' out-of-pocket costs and costs due to productivity losses will be included in the economic evaluation.
- Secondary Outcome Measures
Name Time Method To study whether nurse-led self-help for patients with recurrent MDD versus usual care alone:<br /><br>1. Is (cost-)effective in reducing health care utilisation;<br /><br>2. Is (cost-)effective in reducing co-morbid distress, anxiety and somatisation;<br /><br>3. Is satisfying according to patients;<br /><br>4. Is (cost-)effective in certain subgroups of patients, particularly related to (i.e. modified by):<br /><br>A. The number of previous episodes;<br /><br>B. Type of treatment for the last recurrence (AD, psychological intervention, noting etc);<br /><br>C. The severity of residual depressive symptoms in the remitted phase;<br /><br>D. Age of onset of the first depressive episode;<br /><br>E. Social economic status;<br /><br>F. Self-efficacy for managing depression;<br /><br>G. Symptoms of pain and/or fatigue.