Supportive Care and Antibiotics for Severe Pneumonia among Hospitalised Children (SEARCH): A Pragmatic Randomised Controlled Trial

niversity of Oxford0 个研究点目标入组 4,392 人开始时间: 2021年6月18日最近更新: 2023年5月29日

试验速览

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•Age 2 to 59 months.
•History of cough or difficulty breathing and signs of severe pneumonia based on WHO 2013 criteria
•Admitted to any one of the study hospitals.
•Informed consent provided by the parents/guardian.

•Children presenting in cardiorespiratory arrest requiring emergency basic life support (bag-valve-mask ventilation and/or chest compressions).
•Children for whom concurrent condition precludes the use of the first-line antibiotics for severe pneumonia such as readmission or meningitis
•Shock due to dehydration or severe dehydration (based on WHO definitions (5)) requiring emergency fluid resuscitation
•Known allergy or contraindication to penicillin, gentamicin, ceftriaxone or amoxicillin-clavulanic acid.
•Referral from another inpatient facility following treatment with injectable antibiotics for more than 24 hours or because the first-line regimen is considered to have failed
•Previously enrolled in the study.
•For Randomisation 2 (IV fluid versus nasogastric feeds): children with absent gag reflex.
•For Randomisation 2 (IV fluid versus nasogastric feeds): children unable to maintain oxygen saturations ?90% on pulse oximetry while receiving supplemental oxygen.
•For Randomisation 2 (IV fluid versus nasogastric feeds): children with severe acute malnutrition

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