Renal Function Determination With Creatinine and Cystatin C Dependent Formulas Compared to Gold Standard DTPA-TC-99 (Diethylene-triamine-pentaacetate- Technetium-99) in Mexican Cirrhotic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Levels of glomerular filtration through several formulas in cirrhotic patients
研究概览
简要总结
We have several ways to appropriately determine renal function in healthy patients and in several diseases, in cirrhotic population we dont have a precise tool that has sufficient precision that reflects glomerular function, although it has been reported that cystatin C, because of its nature could improve diagnostic accuracy to determinate the renal function in this population.
The investigators hypothesize that glomerular filtration obtained from cystatin-C-derived formulas are more accurate when compared to creatinine-derived formulas with DTPA-Tc99 (diethylene-triamine-pentaacetate- technetium-99) as gold standard.
详细描述
The aim of the study is to determine if the formulas for glomerular filtration are close to the estimation of actual renal function in mexican cirrhotic patients of different etiologies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Liver cirrhosis
- •Stability in creatinine levels in the previous three months (variation <0.3 mg/dL)
- •Signed informed consent
排除标准
- •Pregnancy
- •Hepatocellular carcinoma
- •Cerebrovascular events
- •Decompensated heart failure
- •Drugs that modify serum creatinine levels
- •Renal replacement therapy
结局指标
主要结局
Levels of glomerular filtration through several formulas in cirrhotic patients
时间窗: Baseline
Determination of glomerular filtration through several formulas dependent of creatinine and cystatin C and the gold standard
次要结局
未报告次要终点
研究者
ALDO TORRE DELGADILLO
Principal investigator
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran