Renal Function Determination in Patients With Liver Cirrhosis
- Conditions
- Liver Cirrhosis
- Registration Number
- NCT02047240
- Lead Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- Brief Summary
We have several ways to appropriately determine renal function in healthy patients and in several diseases, in cirrhotic population we dont have a precise tool that has sufficient precision that reflects glomerular function, although it has been reported that cystatin C, because of its nature could improve diagnostic accuracy to determinate the renal function in this population.
The investigators hypothesize that glomerular filtration obtained from cystatin-C-derived formulas are more accurate when compared to creatinine-derived formulas with DTPA-Tc99 (diethylene-triamine-pentaacetate- technetium-99) as gold standard.
- Detailed Description
The aim of the study is to determine if the formulas for glomerular filtration are close to the estimation of actual renal function in mexican cirrhotic patients of different etiologies.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 92
- Liver cirrhosis
- Stability in creatinine levels in the previous three months (variation <0.3 mg/dL)
- Signed informed consent
- Pregnancy
- Hepatocellular carcinoma
- Cerebrovascular events
- Decompensated heart failure
- Drugs that modify serum creatinine levels
- Renal replacement therapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Levels of glomerular filtration through several formulas in cirrhotic patients Baseline Determination of glomerular filtration through several formulas dependent of creatinine and cystatin C and the gold standard
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"
🇲🇽Mexico City, DF, Mexico