Clinical EvaluatioN of TElmisartan-based Antihypertensive Regimen (CENTER)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15,268
- 试验地点
- 1
- 主要终点
- Response Rate at the End of 30 Day Period
研究概览
简要总结
To determine the efficacy and safety of telmisartan-based treatment among patients with metabolic syndrome in actual setting in Philippines.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 45 years
- •Increased waist circumference (>88.9cm [>35in] men, >78.7cm [>31in] for women)
- •Elevated triglycerides (>150mg/dl)
- •Low HDL cholesterol (<40mg/dl in men, <50mg/dl in women)
- •Hypertension (>130/>85mmHG)
- •Impaired fasting glucose (>110mg/dl) (8)
- •Hypertensive patient assessed to benefit from telmisartan based treatment
排除标准
- •Hypersensitivity to telmisartan, hydrochlorothiazide (HCTZ) and its excipients
- •<3 months myocardial infarction (MI), stroke or severe heart failure
结局指标
主要结局
Response Rate at the End of 30 Day Period
时间窗: End of 30 day Period
Response rate of Blood Pressure assessed in the following categories: * Sitting SBP \< 130 mmHg and/or a reduction of \> 20 mmHg from baseline * Sitting DBP \< 85 mmHg and/or a reduction of \> 10 mmHg from baseline Sitting BP normalization \< 130 mmHg and DBP \< 85 mmHg
Response Rate at the End of 60 Day Period
时间窗: At the end of 60 day period
Response rate on Blood Pressure: 1. Sitting SBP \< 130 mmHg and/or a reduction of \> 20 mmHg from baseline. 2. Sitting DBP \< 85 mmHg and/or a reduction of \> 10 mmHg from baseline. 3. Sitting BP normalization \< 130 mmHg and DBP \< 85 mmHg
Change in Systolic Blood Pressure (SBP) From Baseline
时间窗: Baseline and 60 days
Change in SBP = Value in visit 1(baseline) minus value in visit 3 (at 60-day treatment period)
Change in Diastolic Blood Pressure (DBP) From Baseline
时间窗: Baseline and 60 days
Change in DBP = Value in visit 1(baseline) minus value in visit 3 (at 60-day treatment period)
次要结局
- Percentage of Patients With Presence of Metabolic Risk Factor(At the end of 60 day period)