Liver Function Abnormalities in Patients With Acute Heart Failure

Not yet recruiting

• Conditions: Acute Heart Failure
• Interventions: Behavioral: Avoiding the risk factors

• Registration Number: NCT06491628
• Lead Sponsor: Sohag University

Brief Summary

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

Detailed Description

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure.

The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF.

Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).

Study Timeline

• Status Verified: 2024-07
• Study Start: 2024-07-01
• Study First Submitted: 2024-07-01
• Study First Submitted QC: 2024-07-01
• Last Update Submitted: 2024-07-08
• Study First Posted: 2024-07-09
• Last Update Posted: 2024-07-10
• Primary Completion: 2025-07
• Study Completion: 2025-08

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients aged 18 yrs or older presenting with AHF

Exclusion Criteria

• Congenital heart disease
• acute and chronic liver diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hypertensive acute heart failure	Avoiding the risk factors	the condition is associated with elevated blood pressure with accompanying dyspnea. orthopnea and pulmonary congestion, often in patients with relatively preserved left ventricle ejection fraction
cardiogenic shock	Avoiding the risk factors	severe peripheral hypoperfusion wih subsequent end organs damage,typically it's associated with low blood pressure and low urine output
Pulmonary edema	Avoiding the risk factors	It's the real clinical presentation of AHF, typically, signs and symptoms develope rapidly and patients demonstrate severe respiratory distress with tachypnea, orthopnea and pulmonary congestion
Acute coronary syndrome complicated by heart failure	Avoiding the risk factors	characterized by complex structural, hemodynamic and neurohormonal interaction need urgent referral for coronary intervention poor outcome
Acute decompensated heart failure (de novo or as decompensation of chronic heart failure)	Avoiding the risk factors	This umbrella term includes patients presenting forthe first time with typical symptoms and signs of heart failure(de novo AHF) and also those with worsening of their pre-existing cardiomyopathy (acute decompensated heart failure).

Primary Outcome Measures

Name	Time	Method
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals	baseline	assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Secondary Outcome Measures

Name	Time	Method
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals	1 year	assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Trial Locations

Locations (1)

Sohag university; 🇪🇬 Sohag, Egypt