Elucidating the Symptomatic, Explanatory and Prognostic Characteristics of GERIAtric Patients Hospitalized for COVID-19

• Conditions: Covid19

• Registration Number: NCT04560608
• Lead Sponsor: University Hospital, Angers

Brief Summary

Statement :

* The emerging Coronavirus 2019 (COVID-19) disease, linked to the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathogen, has been spreading worldwide since December 2019, affecting millions of people and causing hundreds of thousands of deaths, particularly among the elderly.

* The first epidemiological evidence available reveals a different expression of the disease in the elderly, associated with a high risk of delayed diagnosis and implementation of protective measures and a particularly high morbidity and mortality, especially among the frailest.

* To date, there is no effective model for predicting the severity of COVID-19 in an individual.

The investigators hypothesize that there are specificities of COVID-19 in the elderly, both etiological, diagnostic and prognostic, all of which are not yet known and understood.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-15
• Study First Submitted: 2020-09-08
• Study First Submitted QC: 2020-09-21
• Study First Posted: 2020-09-23
• Status Verified: 2021-12
• Last Update Submitted: 2021-12-03
• Last Update Posted: 2021-12-20
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 700

Inclusion Criteria

• Hospitalization in the Geriatric unit of the University Hospital (UH) of Angers from 15/03/2020 and until the closure of the COVID-19 geriatric sector

Exclusion Criteria

• Opposition to the use of the information collected for research purposes.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Medical history and co-morbidities	baseline	listing of medical history and co-morbidities data provided by the physician and the family during hospitalization
Number of different therapeutic classes	baseline	Number of different therapeutic classes taken per day.
Medical imaging results	baseline	Assessment of lesion extension (percent) with medical imaging results (thoracic scan)
Diagnosis of COVID-19	baseline	Recovery of the diagnosis method (PCR or thoracic scan)
The physical examination data, and reports of relevant investigations data provided by the physician and the family during hospitalization	baseline	The demographic characteristics are age, sex, marital status, place of life, career, presence of un/formal assistance, ...
Electrocardiography QT Interval	baseline	all electrocardiograms performed during hospitalization
Biological parameters	baseline	Characterization of the COVID-19 impact on the biological parameters evaluated by blood test.
Reports of relevant investigations data provided by the physician and the family during the two-month telephone follow-up	at the 12-month follow-up	The demographic characteristics are age, sex, marital status, place of life, career, presence of un/formal assistance, ...
Comprehensive Geriatric Assessment (CGA)	baseline	Comprehensive geriatric assessment (CGA) is defined as a multidisciplinary diagnostic and treatment process that identifies medical, psychosocial, and functional capabilities of an older adult in order to develop a coordinated plan to maximize overall health with aging. CGA is based on the premise that a systematic evaluation of frail older persons by a team of health professionals may identify a variety of treatable health problems and lead to better health outcomes.
Length of hospitalization	at the 12-month follow-up
Number of death from any cause	at the 12-month follow-up

Trial Locations

Locations (1)

Angers University Hospital; 🇫🇷 Angers, France