A Randomized, Controlled, Double-blind, Multicenter Clinical Study of the Electroacupuncture Treatment on Muscle and Bone Balance of Knee Osteoarthritis
- Conditions
- Knee Osteoarthritis
- Registration Number
- ITMCTR2000003638
- Lead Sponsor
- Shanghai Longhua Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Patients who meet the western medicine diagnostic criteria of knee osteoarthritis;
2. Aged between 50 and 75 years;
3. Patients in line the level of radiological classification for knee osteoarthritis degeneration;
4. Patients who did not use glucocorticoid via oral administration or intramuscular, articular, or soft tissue injection four weeks before accepting the test agent;
5. Patients who signed the informed consent and ensured the compliance.
1. Patients with long-term oral administration of agents for knee osteoarthritis, and still in the drug effect period, without elution;
2. Patients with severe heart, brain, liver, kidney or lung dysfunction;
3. Patients with other knee diseases found in arthroscopic surgery;
4. Patients who have accepted other relevant treatments, which may affect the observation on the effects of this study;
5. Patients with mental illness;
6. Patients with coagulation dysfunction;
7. Patients with articular surgical treatment;
8. Patients with an indication for joint surgery
9. Patients with a history of abuse of opioid analgesics, sedative hypnotics or alcohol;
10. Patients with poor compliance, who were unable to meet the requirements for follow-up.
11. Pregnant and lactating women.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method equesne index;VAS score;Six-minute walking test;WOMAC;The Medical Outcomes Study short form health survey-36;
- Secondary Outcome Measures
Name Time Method ltrasound of the knee joint;3D Gait Analysis;Proteome resequencing: peripheral blood.;Isometric muscle strength test;Knee CT;NIR-ICG near-infrared detection;inguinal lymph node ultrasound;