Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study

Fondation Ophtalmologique Adolphe de Rothschild0 个研究点目标入组 90 人开始时间: 2026年8月15日最近更新: 2026年1月20日

适应症

试验速览

阶段: 不适用
状态: 尚未招募
发起方: Fondation Ophtalmologique Adolphe de Rothschild
入组人数: 90
主要终点: neutrophil polynuclear cells levels

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC.
•Inclusion Criteria Control:
•- For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.
•Non-inclusion Criteria Patients:
•HD carried out in a context of acute cerebral haemorrhage
•Pre-existing neurological disability: modified Rankin score > 2
•Patient benefiting from a legal protection measure
•Non-inclusion Criteria Controls:
•Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage.
•Patient operated on for an osteomeningeal pathology present at the approach site.
•Patient operated on for an infectious cranial or neuro-meningeal pathology.
•Patient to be operated on as a result of an intracranial traumatic condition

排除标准

未提供

结局指标

主要结局

neutrophil polynuclear cells levels

时间窗: Day 0

次要结局

未报告次要终点

研究者

发起方

Fondation Ophtalmologique Adolphe de Rothschild

申办方类型

Network

责任方

Sponsor

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