A randomised control trial of cognitive training and non-invasive brain stimulation in Parkinson's: The impact on cognition (thinking skills) and quality of life.

Not Applicable

Recruiting

Conditions: Parkinson's disease
Mild Cognitive Impairment
Neurological - Parkinson's disease

Registration Number: ACTRN12618000999235

Lead Sponsor: Professor Natalie Gasson

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 45

Inclusion Criteria

1) Diagnosed with idiopathic PD by a neurologist or geriatrician in accordance with the
United Kingdom Parkinson’s Disease Society Brain Bank Clinical (UKPDSBBC) criteria.
2) Self-reported problems with cognition which do not significantly impact on functional
independence.
3) Presence of MCI in accordance with the MDS PD-MCI Level II diagnostic criteria, using an SD level of 1.5.
4) Stable response to antiparkinsonian medication for a minimum period of 2 months.

Exclusion Criteria

1) Presence of PD-Dementia.
2) Recent history of brain surgery.
3) Deep Brain Stimulation (DBS) implant.
4) Active skin disease on the scalp.
5) History of migraine.
6) History of epilepsy.
7) Unstable medical condition (e.g., uncontrolled diabetes)
8) Metal implants in the head/brain.
9) Currently using a hearing aid.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mild Cognitive Impairment Scores (as measured using the Movement Disorder Society Level II Diagnostic Criteria for Parkinson's disease - Mild Cognitive Impairment).<br>This involves two measures for each of five domains:<br>1. Letter-Number Sequencing subtest from the Wechsler Adult Intelligence Scale-IV (WAIS-IV; attention & working memory)<br>2. Stroop (Colour-Word) Test (attention)<br>3. CANTAB Stockings of Cambridge subtest (executive function)<br>4. Controlled Oral Word Association Task (executive function)<br>5. Boston Naming Test (language)<br>6. Similarities subtest of the WAIS-IV (language)<br>7. Hopkins Verbal Learning Test-Revised (memory)<br>8. Location Learning Test (memory)<br>9. Judgement of Line Orientation Test (visuo-spatial)<br>10. Hooper Visual Organisation Test (visuo-spatial)<br>[ 1. Baseline (1 week prior to intervention)<br>2. Post-Intervention (1 week after intervention) [Primary Timepoint]<br>3. Follow-up (12 weeks after intervention)]

Secondary Outcome Measures

Name	Time	Method
Means scores Parkinson's Disease Questionnaire 39 (PDQ-39)[ 1. Baseline (1 week prior to intervention)<br>2. Post-Intervention (1 week after intervention)<br>3. Follow-up (12 weeks after intervention)]