Effects of Cimetidine on Cisplatin-induced Nephrotoxicity.
- Conditions
- - irresectable and/or metastatic Head and Neck cancer.- treatment with Cisplatin.
- Registration Number
- NL-OMON21483
- Lead Sponsor
- Erasmus MC Rotterdam-Daniel den Hoed Cancer Center
- Brief Summary
Sprowl et al. Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther 2013;94(5):585-92
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
1. Histological or cytological confirmed diagnosis of any form of irresectable and/or metastatic Head and Neck cancer, which is not currently being treated with cisplatin;
2. Treatment with high doses of cisplatin (3-weekly 100 mg/m2), with radiotherapy. No other systemic anti-cancer treatment is allowed;
1. Pregnant or lactating patients; patients with reproductive potential must use a reliable method of contraception (excluding oral contraceptives), if required;
2. Serious illness or medical unstable condition requiring treatment, symptomatic CNS-metastases or history of psychiatric disorder that would prohibit the understanding and giving of informed consent;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate the ability of cimetidine to prevent cisplatin-induced nephrotoxicity, while not impairing the efficacy of cisplatin in Head and Neck cancer patients.<br /><br>Urine and blood work will be done to establish baseline kidney function/damage.
- Secondary Outcome Measures
Name Time Method