Effects of Cimetidine on Cisplatin-induced Nephrotoxicity.

Erasmus MC Rotterdam-Daniel den Hoed Cancer Center0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 20

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

Sprowl et al. Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther 2013;94(5):585-92

研究设计

研究类型: Interventional

入排标准

入选标准

•1. Histological or cytological confirmed diagnosis of any form of irresectable and/or metastatic Head and Neck cancer, which is not currently being treated with cisplatin;
•2. Treatment with high doses of cisplatin (3-weekly 100 mg/m2), with radiotherapy. No other systemic anti-cancer treatment is allowed;

排除标准

•1. Pregnant or lactating patients; patients with reproductive potential must use a reliable method of contraception (excluding oral contraceptives), if required;
•2. Serious illness or medical unstable condition requiring treatment, symptomatic CNS-metastases or history of psychiatric disorder that would prohibit the understanding and giving of informed consent;

研究者

发起方

Erasmus MC Rotterdam-Daniel den Hoed Cancer Center

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