Pre-anesthesia Pleth Variability Index as a Predictor for Post-induction Hypotension in Elderly Patients Undergoing General Anesthesia: A Prospective Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Post-induction Hypotension
- Sponsor
- Cairo University
- Enrollment
- 85
- Locations
- 1
- Primary Endpoint
- The accuracy (Area under receiver operating characteristic curves) of pre-induction PVI for prediction of post-induction hypotension
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Hypotension after induction of general anesthesia and before surgical stimulation is a prevalent anesthesia-related side effect. The post-induction hypotension disrupts organ perfusion and may cause organ damage particularly acute kidney injury, cerebrovascular stroke, and myocardial ischemia. Post-induction hypotension occurs with greater frequency and severity in the elderly. This is because of aged-related diminished cardiac reserve and impaired autonomic homeostasis. Pleth variability index (PVI) is a software program that measures the dynamic changes of the PI that occurs during a complete respiratory cycle. Our primary outcome is to determine the predictive ability and the optimal cut-off value of pre-anesthesia PVI for predicting elderly patients who are at risk of developing post-induction hypotension
Investigators
Abeer Ahmed, MD
Assistant Professor of Anesthesia, SICU & pain management. Kasralainy Faculty of medicine
Cairo University
Eligibility Criteria
Inclusion Criteria
- •patients with ASA physical status I or II
- •patients will receive general anesthesia
Exclusion Criteria
- •Patients with a history of cardiorespiratory disorders
- •patients with uncontrolled hypertension or cardiac dysrhythmias
- •Patients with renal or hepatic diseases.
- •Patients with long-standing diabetes and peripheral vascular diseases.
Outcomes
Primary Outcomes
The accuracy (Area under receiver operating characteristic curves) of pre-induction PVI for prediction of post-induction hypotension
Time Frame: before induction of general anesthesia