Comparison of the Cosmetic Effects of Bakuchiol and Retinol

Early Phase 1

Completed

Brief Summary: Subjects will be assigned to a retinoid cream or bakuchiol to compare the cosmetic effects. This will take place over a 12 week period.

Detailed Description: Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side-effects.

The aim of this study is to compare the cosmetic effects of Bakuchiol to Retinol over a 12-week period.

Recruitment & Eligibility

Inclusion Criteria

• Individuals aged 30-55

Exclusion Criteria

Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Pregnant or breast feeding women
Prisoners
Those with acne, eczema, seborrheic dermatitis, rosacea or polycystic ovarian syndrome
Those who have used isotretinoin in the last 6 months
Those who have used products containing salicylic acid, beta hydroxyl acids or vitamins A, C, or E in the last 14 days
Those who have used topical antibiotics or topical retinoids in the last 30 days
Those who are currently smoking or have smoked within the past 3 years.
Those who have had a recent surgical or cosmetic procedure in the last 3 months that can affect facial wrinkles or facial hyperpigmentation, such as botulinum toxin injections, chemical peels, laser based therapies to the face, or face lift surgeries

Arm && Interventions

Group	Intervention	Description
Bakuchiol	Bakuchiol	Bakuchiol 0.5% applied to face twice daily
Retinol	Retinol	0.5% retinol applied to face nightly

Primary Outcome Measures

Name	Time	Method
Change in Wrinkle Appearance	12 week	Assessed using image analysis based assessment of wrinkle severity (depth and length). The primary outcome measure was image-analysis-based assessment of wrinkle severity and pigmentation at 12 weeks.
Percentage of Participants With Change in Appearance of Skin Pigmentation	12 week	Assessed using image analysis based assessment of facial pigment

Secondary Outcome Measures

Name	Time	Method
Number of Reports of Facial Erythema Assessment	week 4, week 8 and week 12	Image analysis based assessment of facial erythema
Number of Reports of Stinging, Burning, Itching	Assessed at Week 4, 8, and 12.	Subjective tolerability assessment of stinging, burning, itching. Secondary outcome measures included redness, participant-reported tolerability (itching, burning and stinging) and in-person clinical assessments (pigmentation, scaling and erythema) throughout the study.