Comparison of the Cosmetic Effects of Bakuchiol and Retinol
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Change in Wrinkle Appearance
研究概览
简要总结
Subjects will be assigned to a retinoid cream or bakuchiol to compare the cosmetic effects. This will take place over a 12 week period.
详细描述
Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side-effects.
The aim of this study is to compare the cosmetic effects of Bakuchiol to Retinol over a 12-week period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals aged 30-55
排除标准
- •Adults unable to consent
- •Individuals who are not yet adults (infants, children, teenagers)
- •Pregnant or breast feeding women
- •Prisoners
- •Those with acne, eczema, seborrheic dermatitis, rosacea or polycystic ovarian syndrome
- •Those who have used isotretinoin in the last 6 months
- •Those who have used products containing salicylic acid, beta hydroxyl acids or vitamins A, C, or E in the last 14 days
- •Those who have used topical antibiotics or topical retinoids in the last 30 days
- •Those who are currently smoking or have smoked within the past 3 years.
- •Those who have had a recent surgical or cosmetic procedure in the last 3 months that can affect facial wrinkles or facial hyperpigmentation, such as botulinum toxin injections, chemical peels, laser based therapies to the face, or face lift surgeries
研究组 & 干预措施
Bakuchiol
Bakuchiol 0.5% applied to face twice daily
干预措施: Bakuchiol (Drug)
Retinol
0.5% retinol applied to face nightly
干预措施: Retinol (Drug)
结局指标
主要结局
Change in Wrinkle Appearance
时间窗: 12 week
Assessed using image analysis based assessment of wrinkle severity (depth and length). The primary outcome measure was image-analysis-based assessment of wrinkle severity and pigmentation at 12 weeks.
Percentage of Participants With Change in Appearance of Skin Pigmentation
时间窗: 12 week
Assessed using image analysis based assessment of facial pigment
次要结局
- Number of Reports of Facial Erythema Assessment(week 4, week 8 and week 12)
- Number of Reports of Stinging, Burning, Itching(Assessed at Week 4, 8, and 12.)