Physical activity and abdominal subcutaneous adipose tissue biology in middle-aged lean and obese individuals
Completed
- Conditions
- total energy expenditure10012653
- Registration Number
- NL-OMON32843
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 72
Inclusion Criteria
- Men and women
- Age: 40-65 years
- Body mass index: 20-25 kg/m2 and 27-35 kg/m2
Exclusion Criteria
- Body mass index < 20 or >35 kg/m2
- patients with metabolic syndrome or type 2 diabetes mellitus
- pregnancy or the intention to becom pregnant
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary objective of the proposed study is to investigate the level of<br /><br>physical activity among lean and obese middle-aged individuals. We hypothesize<br /><br>that the level of physical activity among healthy (obese) subjects is higher<br /><br>than in patients with type 2 diabetes mellitus. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Furthermore, we hypothesize that obese and lean individuals differ with respect<br /><br>to smaller adipose tissue cell size, lower inflammatory markers and fat<br /><br>hormones expression (i.e. hsCRP, IL6/18 and leptin) in subcutaneous adipose<br /><br>tissue compared to patients with type 2 diabetes mellitus (prior to the start<br /><br>of insulin therapy).</p><br>