Effect of Positive End-Expiratory Pressure Titration on Venous Excess Ultrasound Score and Renal Outcomes in Patients With Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- VExUS score
研究概览
简要总结
This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS to assess the effect of different levels of PEEP titration on VExUS score and renal outcomes in patients with Acute Respiratory Distress Syndrome.
详细描述
This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS within 24 hours of onset and mechanically ventilated for more than 24 hours to assess the effect of different levels of PEEP titration on Venous Excess Ultrasound Score and renal outcomes in patients with Acute Respiratory Distress Syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 18 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •Diagnosis of ARDS according to the Berlin criteria.
- •Invasive mechanical ventilation ≥24 hours.
- •Requirement of PEEP ≥5 cmH₂O.
排除标准
- •Known end-stage renal disease on chronic dialysis.
- •History of renal transplantation.
- •Pregnancy.
- •Known severe tricuspid regurgitation.
- •Chronic liver disease with portal hypertension.
- •Poor ultrasound window precluding adequate venous Doppler assessment.
结局指标
主要结局
VExUS score
时间窗: 3 days
Change in VExUS score in relation to different PEEP levels in mechanically ventilated patients with ARDS.
Development of acute kidney injury (AKI)
时间窗: 3 days
Development of acute kidney injury (AKI), defined and staged according to the KDIGO criteria: increase in serum creatinine by ≥0.3 mg/dL within 48 hours, or ≥1.5 times baseline within 7 days, or urine output \<0.5 mL/kg/hour for 6 hours.
次要结局
- Requirement for renal replacement therapy (RRT) during ICU stay.(3 days)
- Length of ICU stay(4 to 7 days)
- ICU mortality(4 to 7 days)
研究者
Hager Rabie Elsofey Mohammed
Assistant Lecturer of Critical Care Medicine
Fayoum University