Escalating Ketamine Doses and Pre-emption
- Registration Number
- NCT01070108
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Brief Summary
Ketamine affects postoperative pain when administered intravenously immediately before, during or at the end of surgical procedures. We assessed the effects of multiple and escalating doses of ketamine administered many hours before surgery on postoperative pain and analgesia consumption.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Consecutive patients, who were scheduled to undergo general or orthopedic oncologic surgery under general anesthesia
Exclusion Criteria
- allergy to opioids, ketamine or non-steroidal anti-inflammatory drugs (NSAIDs)
- history of lasting chronic pain or psychiatric disorders or had used opioids or psychotropic drugs of any sort during the past two weeks
- soldiers and pregnant women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Set 1 ketamine group receiving one injection (25 mg) of ketamine (K1) intramuscularly (IM) at 3-4 hours before surgery or placebo (saline 0.9%, NS) set 2 ketamine 2nd set received ketamine at 11-12 hours (10 mg) and 3-4 hours (25 mg) before surgery (K2), with a corresponding NS group set 3 ketamine 3rd set one group had ketamine injected IM 17-18, 11-12, and 3-4 hours before surgery (5, 10 and 25 mg, respectively) (K3), and the second group received NS
- Primary Outcome Measures
Name Time Method postoperative pain 48 hours
- Secondary Outcome Measures
Name Time Method opioid drug consumption 48 hours
Trial Locations
- Locations (1)
Tel Aviv Medical Center
🇮🇱Tel Aviv, Israel