The Effect of Exercise in Postmenopausal Women with Low Bone Density

University of Melbourne1 site in 1 country38 target enrollmentFebruary 2001

ConditionsOsteoporosis Osteopenia

Overview

Phase: Phase 2
Intervention: Not specified
Conditions: Osteoporosis
Sponsor: University of Melbourne
Enrollment: 38
Locations: 1
Primary Endpoint: Bone density measured using DXA at the lumbar spine and proximal femur
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This clinical trial aims to evaluate the effects of a 12 month gym- and home-based exercise program on bone density and falls risk factors in postmenopausal women with low bone density. It is hypothesised that the exercise program will lead to improvements in bone density and falls risk factors such as balance and muscle strength compared with usual care.

Registry

clinicaltrials.gov

Start Date

February 2001

End Date

November 2007

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

University of Melbourne

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Be aged greater than 50 years
•Be at least 5 years post menopause (defined as the last normal menstrual bleed)
•Have osteopenia of the hip defined as a DXA T-score between -1 and -2.5 in one or more regions of the proximal femur (total hip, neck or trochanter regions).
•Have primary osteopenia
•Be community dwelling (not in residential care)
•Be able to attend an exercise program 3 times per week over the 12-month period
•Be able to read and write English

Exclusion Criteria

•Secondary causes of bone loss such as osteomalacia, glucocorticoid medication
•Co-morbidities that would interfere with participation in exercise such as severe heart or pulmonary disease, inflammatory joint disease, severe osteoarthritis, psychiatric condition
•Physical or orthopaedic disabilities that would place the subject at risk or limit their ability to perform exercise
•Spinal osteoporosis defined as DXA T-score \<-2.5
•A past vertebral fracture
•Body mass index \> 35 or \<
•Currently on hormone replacement therapy (HRT)
•Current smoker
•Past use of HRT within the past 3 years and for more than 6 months duration
•Taking medication known to affect bone including oestrogen or steroid hormones