A clinical trial to study the effect of platelet rich plasma on canine retraction in orthodontic patients.
- Registration Number
- CTRI/2024/04/066015
- Lead Sponsor
- Arushi Malhotra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Age range 16-25 years
Critical anchorage
Adequate interradicular distance between the maxillary first permanent molar and second premolar for insertion of mini screws.
Good gingival and periodontal health (probing depth =3mm,gingival index score =1).
No systemic disease
Full development of teeth except 3rdmolars.
Patients requiring bilateral extraction of maxillary 1st premolar as part of their comprehensive treatment.
Platelet count above 100000/mL.
Clotting or bleeding disorders.
Smokers, alcoholism
Pregnancy
Systemic disease or medications intake that interfere with orthodontic tooth movement or platelet count.
Sign and symptom of periodontal disease.
Gingival inflammation. (gingivitis)
Poor oral hygiene for = 2 visits.
History of previous orthodontic treatment.
Dental caries.
Long term use of antibiotics,phenytoin, cyclosporine,anti-inflammatory drugs, systemic corticosteroids and calcium channel blockers.
Crossbite or deviation during jaw closure caused by occlusal interferences.
Patient with severe tooth displacement (eg ectopic canine)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The predictor variable is the canine retraction technique i.e canine retraction with and without PRP injection. The canine retraction rate is our primary outcome.Timepoint: Base time point T0, then every monthly time point till four months i.e. T1, T2, T3, T4
- Secondary Outcome Measures
Name Time Method Canine Rotations & molar rotations will be measured at monthly time intervals till 4 months from the base time pointTimepoint: base time point T0, then monthly intervals T1, T2, T3 & T4;Pain scores will be measured on VAS at base point, at 24 hours & after 7 daysTimepoint: base point, at 24 hours , after 7 days