The Status of Parathyroid Hormone Secretion and Its Relationship With White Blood Cells, Neutrophil / Lymphocyte Ratio, c Reactive Protein, Fibrinogen, Procalcitonin, Ferritin and D-dimer in Hospitalized Covid-19 Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- White blood cells (WBC) results of Covid 19 patient group
研究概览
简要总结
COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation in various organs of the body, especially through cytokines in the lungs. This cytokine-mediated widespread inflammation can also affect the parathyroid glands, resulting in impaired parathyroid secretion.
Researchers evaluated the levels of parathyroid hormone, calcium, phosphorus, and alkaline phosphatase in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known parathyroid disease.
The researchers examined the association of parathyroid hormone secretion with COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, C reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone level of healthy people without COVID-19 infection and known parathyroid disease with the parathyroid hormone level of Covid-19 patients.
详细描述
The coronavirus-2 (SARS-COV-2) virus, which can cause severe acute respiratory syndrome through the droplet, has caused the global Coronavirus 19 (COVID-19) pandemic. COVID-19 infection can be asymptomatic or lead to serious illness and even death. This virus causes a hypersensitive immune reaction and varying degrees of widespread inflammation through cytokines in various organs of the body, mainly the lungs.
Cytokine-mediated widespread inflammation caused by the virus may also affect the parathyroid glands, causing their functions to deteriorate. Thus, it may cause changes in parathyroid hormone secretion.
The researchers evaluated the results of serum parathyroid hormone, calcium, phosphorus, alkaline phosphatase tests in patients who were symptomatic and hospitalized with COVID-19 infection. Participants also evaluated the relationship of parathormone with white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone levels of patients with COVID-19 infection with the parathyroid hormone levels of healthy individuals without COVID-19 infection and parathyroid disease. So the investigators looked for differences in parathyroid hormone levels between both groups. Researchers did not include patients in the intensive care unit and patients with known parathyroid disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •To accept research.
- •Being over the age of
- •COVID 19 test results to be positive.
- •Not taking parathyroid disease medication before.
- •Receiving inpatient treatment in the COVID service in the hospital.
排除标准
- •Not accepting research.
- •Be under the age of
- •Negative COVID 19 test results for patients.
- •COVID patients treated as outpatient.
- •Parathyroid disease in the healthy control group.
结局指标
主要结局
White blood cells (WBC) results of Covid 19 patient group
时间窗: 90 days
In the study, serum WBC results were recorded in Covid 19 patient groups.
Comparison of phosphorus between groups
时间窗: 90 days
In the study, serum phosphorus results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
Neutrophil / lymphocyte ratio (N/LO) results of Covid 19 patient group
时间窗: 90 days
In the study, serum N/LO results were recorded in Covid 19 patient groups.
C-reactive protein (CRP) results of Covid 19 patient group
时间窗: 90 days
In the study, serum CRP results were recorded in Covid 19 patient groups.
Comparison of parathyroid hormone between groups
时间窗: 90 days
In the study, serum parathyroid hormone results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
Ferritin results of Covid 19 patient group
时间窗: 90 days
In the study, serum ferritin results were recorded in Covid 19 patient groups.
Comparison of calcium between groups
时间窗: 90 days
In the study, serum calcium results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
Fibrinogen results of Covid 19 patient group
时间窗: 90 days
In the study, serum fibrinogen results were recorded in Covid 19 patient groups.
Comparison of alkaline phosphatase between groups
时间窗: 90 days
In the study, serum alkaline phosphatase results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
Procalcitonin results of Covid 19 patient group
时间窗: 90 days
In the study, serum procalcitonin results were recorded in Covid 19 patient groups.
D-dimer results of Covid 19 patient group
时间窗: 90 days
In the study, serum D-dimer results were recorded in Covid 19 patient groups.
次要结局
未报告次要终点
研究者
Sabahattin Destek
Associate Professor
Bezmialem Vakif University