Screening for Neurodevelopmental Disorders in Siblings of Children with Autism Diagnosed in Tertiary Centers
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 384
- Locations
- 1
- Primary Endpoint
- Percentage of family participation
Study Overview
Brief Summary
In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done. The main aims are to estimate the prevalence of NDD among siblings and to evaluate the feasibility and acceptability of a standardized screening procedure.
Detailed Description
Although NDD are frequent among siblings of children with ASD, their developmental screening is not yet sufficiently organized in routine practice. The needs and the characteristics of these siblings have yet to be better understood in order to define their developmental surveillance.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 2 Years to 16 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Step 1: Brothers or sisters (including stepsisters and brothers); aged between 2 and 16 years; living in Occitanie; informed and express consent of parents ; affiliated to social security.
- •Step 2: step 1 positive screening or parental concerns for child's development ; parental signed informed consent.
Exclusion Criteria
- •Parents (or child) refusal to participate; adopted brother or sister. Do not speak French
Outcomes
Primary Outcomes
Percentage of family participation
Time Frame: 12 months
Families' participation rate and, among participants, number of children with a NDD diagnosis at the end of the screening study.
Secondary Outcomes
- Sensibility, specificity, positive predictive values (PPV) and negative predictive values (NPV) of the screening procedure(12 months)
- Percentage of satisfied parents(12 months)
Investigators
Véronique GONNIER
child psychiatrist
University Hospital, Montpellier