The Effect and Mechanism of Improving Diabetes by Reconstruction Methods in Gastric Cancer Patients With DM Who Receive Surgical Treatment
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Blood sugar stabilization after gastrectomy
研究概览
简要总结
This study is to investigate the effect of gastrectomy on remission of type 2 diabetes in patients with gastric cancer and type 2 diabetes, to investigate the mechanism of blood glucose alteration and intestinal hormonal signaling by the reconstruction methods, and to evaluate the applicability and efficacy of Roux-en-Y gastrojejunostomy after gastrectomy in gastric cancer patients with diabetes.
详细描述
Purpose:
- To investigate the effect of gastrectomy on remission of type 2 diabetes in patients with gastric cancer and type 2 diabetes
- To investigate the mechanism of blood glucose alteration and intestinal hormonal signaling by the reconstruction methods
- To evaluate the applicability and efficacy of Roux-en-Y gastrojejunostomy after gastrectomy in gastric cancer patients with diabetes
Contents:
-
Evaluation of the status of diabetes in gastric cancer patients with DM after gastrectomy
-
Comparison of two reconstruction types after gastrectomy Bypass duodenum and upper jejunum: Roux-en-Y gastrojejunostomy Preservation of duodenal passage: Gastroduodenostomy
-
Analysis for biochemical markers reflecting diabetic status: fasting glucose, postprandial 2h glucose, HbA1c, C-peptide, lipid profile
-
Correlation of parameters associated with diabetes and GI hormones
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient who are older than 20 years and younger than 80 years
- •Histologically confirmed gastric adenocarcinoma located lower one third of stomach
- •Postoperative confirmed pT1N0, pT2N0, pT1N1
- •Informed consent
排除标准
- •Previous history of treatment for other malignancy or inflammatory disease
- •Preoperative uncontrolled serious comorbidity
- •Vulnerable Subjects(pregnant women, children, cognitively impaired persons etc.)
- •Patient who experience any complications requiring reoperation following gastrectomy
结局指标
主要结局
Blood sugar stabilization after gastrectomy
时间窗: three months after surgery
By comparing the difference between fasting blood sugar and postprandial blood glucose, blood sugar stabilization after gastrectomy will be maesured.
次要结局
未报告次要终点
研究者
ji yeong an
assistant professor
Yonsei University