The Role of Vascular Endothelial Markers in Predicting Renal Function Prognosis and Mortality in Patients Undergoing Emergency Hemodialysis Due to Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 试验地点
- 1
研究概览
简要总结
The aim of this study was to evaluate the role of Activin A, Nostrin, and Angiopoetin-2 levels in predicting the prognosis of renal function and in-hospital and 6-month mortality in patients undergoing emergency hemodialysis treatment for acute kidney injury. The main questions it aims to answer are:
Acute renal injury is a clinical entity with very important consequences. Mortality and morbidity are high in patients requiring hemodialysis. This study aims to evaluate the predictive effects of certain biomarkers on outcomes such as short- and long-term monitoring of renal function, weaning or continuation of hemodialysis, in-hospital and 6-month mortality in these patients. In patients with an indication for emergency hemodialysis, the following levels will be measured before hemodialysis:
- Serum Activin A,
- Serum Nostrin,
- Serum Angiopoetin-2
详细描述
In this single-center study, the investigators evaluated patients diagnosed with acute kidney injury (AKI) who underwent emergency hemodialysis. AKI has a high mortality rate and can be accompanied by many complications. Progression to chronic kidney disease is one of the most important of these complications. Identifying prognostic determinants in patients receiving hemodialysis treatment due to AKI can provide significant benefits for clinical practice. In this study, the investigators aimed to determine the prognosis in this patient group using some vascular-endothelial markers. The investigators collected serum samples before hemodialysis from AKI patients indicated for hemodialysis and measured the levels of Activin A, Nostrin, and Angiopoetin-2. The investigators aimed to evaluate the relationship between these levels and parameters such as in-hospital mortality, 6-month mortality, and weaning from hemodialysis after 6 months or hemodialysis dependence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years and older of age requiring hemodialysis for acute kidney injury
排除标准
- •Patients under 18 years of age
- •Patients under chronic renal replacement therapy
- •Patients with a history of renal transplantation
研究组 & 干预措施
AKI-HD GROUP
Acute kidney injury (undergoing hemodialysis) arm. The only group in the study. Measurement of serum Activin A, serum Nostrin, serum Angiopoetin-2
干预措施: Serum samples before hemodialysis. (Diagnostic Test)
研究者
Alper Alp
Associate Professor, MD
Muğla Sıtkı Koçman University