Gingival Crevicular Fluid and Serum Levels of Visfatin in Periodontal Diseases Before and After Non-surgical Periodontal Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 主要终点
- Visfatin levels: Change after periodontal treatment both in serum and GCF
研究概览
简要总结
The purpose of this study was to evaluate visfatin levels in different stages of periodontal diseases and health, moreover the effect of non-surgical periodontal therapy on visfatin levels in Gingival Crevicular Fluid (GCF) and Serum.
详细描述
Total of 45 patients were divided into three groups based on their clinical and radiographical examination. Group 1 chronic periodontitis (n: 15), group 2 plaque induced gingivitis (n: 15) and group 3 Periodontal health (n: 15). GCF and serum samples were collected before treatment and 1, 3, 6 months after treatment and were assayed using enzyme linked immunosorbent assay kit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
- •Systematically healthy patients
- •Group 2 Inclusion Criteria:
- •No alveolar bone and attachment loss
- •Inflammation signs such as redness, edema and increased BOP levels,
- •GI≥2, PPD≤3mm, CAL≤3mm.
- •Systematically healthy patients
- •Group 3 Inclusion Criteria:
- •No bone and attachment loss,
- •GI=0, PPD≤3mm, CAL≤3mm
- •Systematically healthy patients
- •Exclusion Criteria for all groups:
- •Aggressive Periodontitis,
- •Oral pathologies,
- •Patients with any other systemic diseases,
- •Pregnant women and those in the lactation period,
- •Patients with smoking habit and taking medication
- •Patients received periodontal therapy in last 6 months
排除标准
- 未提供
结局指标
主要结局
Visfatin levels: Change after periodontal treatment both in serum and GCF
时间窗: baseline, 1, 3 and 6 months
次要结局
未报告次要终点
研究者
ÇİĞDEM COŞKUN TÜRER
Dr
Bulent Ecevit University