Study of the Biomechanical Anatomy of Ejaculation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Veru montanum mobility and urethral contraction.
研究概览
简要总结
Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ED is a cause for concern for almost a third of patients who need surgery. Surgical techniques have been developed to limit the occurrence of postoperative ED, but their results remain heterogeneous.
There are very few studies on the biomechanical anatomy of ejaculation. Ejaculation is a complex phenomenon involving different structures and in particular the Veru Montanum. This is the key element in the emission of ejaculate within the prostatic urethra. In addition, there is a structure located in the resection zone of the prostate adenoma. It has therefore been suggested that its resection was a primary source of ED.
A single observational study carried out in by Gil Vernet et al in 1994 evaluated on a single healthy 18-year-old volunteer the ejaculatory mechanism of expulsion using an endorectal probe recording the movements of the prostate, the bladder neck and of the proximal urethra during ejaculation.
A contemporary study of the biomechanics of the ejaculatory expulsion phase could confirm and improve understanding of the involvement of anatomical structures. The results of our study aim to adapt surgical techniques aimed at limiting the risk of postoperative ED.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Affiliated subject or beneficiary of a social security scheme
- •Subject agreeing to participate and having signed the free, informed consent.
排除标准
- •Subject with ejaculatory dysfunction
- •Subject with urinary dysfunction
- •History of urinary or penile surgery
- •Subject with untreated urinary tract infection
- •History of chronic prostatitis
- •Pathology making it impossible to introduce the endorectal probe or the ureteroscope
- •History of colorectal inflammatory disease
- •Recent intake (within 30 days) of drugs known to interfere with ejaculation
- •History of intolerance or allergy to any of the drugs used in the study
- •Subject participating in another clinical study
- •Adults under guardianship, curatorship or other legal protection; deprived of liberty by judicial or administrative decision; Hospitalized without consent.
研究组 & 干预措施
Study intervention
Transrectal ultrasound and Urethroscopy
干预措施: Transrectal ultrasound (Other)
Study intervention
Transrectal ultrasound and Urethroscopy
干预措施: Urethroscopy (Other)
结局指标
主要结局
Veru montanum mobility and urethral contraction.
时间窗: At Day 6
Qualitative description of veru montanum mobility and urethral contraction according to urethroscopy videos analysis
Peri-urethral muscle contraction
时间窗: At Day 0
Qualitative description of peri-urethral muscle contraction according to ultrasound videos analysis
Sperm flow within the prostatic urethra
时间窗: At Day 0
Qualitative description of sperm flow within the prostatic urethra according to ultrasound videos analysis
Spermatic fluid via the ejaculatory ducts
时间窗: At Day 6
Qualitative description of the expulsion and flow of spermatic fluid via the ejaculatory ducts according to urethroscopy videos analysis
Urethra, bladder neck and prostate movements
时间窗: At Day 0
Qualitative description of movements of the urethra, bladder neck and prostate according to ultrasound videos analysis
次要结局
未报告次要终点
研究者
Dr Vincent Misrai
Principal Investigator, MD
Clinique Pasteur