Validation of diffusion weighted MR images of laryngeal cancer with histopathology

Completed

Conditions: laryngeal cancer
Laryngeal carcinoma
10027655

Registration Number: NL-OMON55866

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- Patients with a T3 or T4 laryngeal or hypopharyngeal cancer scheduled for
total laryngectomy.
- Age >= 18 years.
- Informed consent.

Exclusion Criteria

- Patients with indications for primary radiotherapy.
- Patients with contraindications for surgery.
- Patients who meet exclusion criteria for MRI at 3T as defined in the
protocols of the Radiology department.
- Patients with contraindication for CT contrast administration as defined in
the protocols of the Radiology department.
- Patients with insulin dependent diabetes mellitus.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The accuracy of DW-MRI in determining the volume of the tumour.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The sensitivity (part of the tumour that is delineated) and positive predictive<br /><br>power (part of the delineated volume that is tumour) of DW-MRI based tumour<br /><br>delineation compared with values obtained using CT, PET and anatomical MR<br /><br>imaging.<br /><br><br /><br>The microscopic extension of the tumour measured as the distance between the<br /><br>gross tumour volume and the most distant microscopic lesions in the<br /><br>histopathology.</p><br>