ISRCTN16912075已完成未知
In adult patients with known or suspected COVID-19, does the use of Continuous Positive Airway Pressure (CPAP) or high-flow nasal oxygen (HFNO), compared with standard care reduce mortality or need for tracheal intubation?
niversity of Warwick0 个研究点目标入组 4,002 人开始时间: 2020年4月6日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 4,002
研究概览
简要总结
2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32727624/ protocol (added 03/08/2020) 2021 Preprint results in https://doi.org/10.1101/2021.08.02.21261379 (added 31/08/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35072713/ (added 25/01/2022)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current participant inclusion criteria as of 04/05/2021:
- •1. Adults =18 years
- •2. Hospital inpatient with suspected or proven COVID-19
- •3. FiO2 =0.4 and SpO2 =94%
- •4. Plan for escalation to intubation if needed
- •Previous participant inclusion criteria:
- •1. Adults = 18 years
- •2. Admitted to hospital with suspected or proven COVID-19
- •3. On 40% oxygen (or greater) with SpO2 <94%
- •4. Plan for escalation to intubation if needed
排除标准
- •Current participant exclusion criteria as of 04/05/2021:
- •1. Planned intubation and mechanical ventilation imminent within 1 hour
- •2. Known or clinically apparent pregnancy
- •3. Any absolute contraindication to CPAP or HFNO
- •4. Decision not to intubate due to ceiling of treatment or withdrawal of treatment anticipated
- •5. Equipment for both CPAP and HFNO not available
- •Previous participant exclusion criteria:
- •1. Planned intubation and mechanical ventilation imminent within 1 hour
- •2. Known or clinically apparent pregnancy
- •3. Any absolute contraindication to CPAP or HFNO
- •4. Decision not to intubate due to ceiling of treatment or withdrawal of care anticipated
- •5. Equipment for both CPAP and HFNO not available
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