A randomized, single-blind, cross-controlled study for the effects of acute cold exposure on blood pressure and angiotensin II levels in humans

Phase 1

Recruiting

• Conditions: Hypertension, hyperlipidemia

• Registration Number: ITMCTR1900002524
• Lead Sponsor: Dongzhimen Hospital, Beijing University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Aged between 18 and 65 years, regardless of gender;
(2) The body mass index is between 18.5-23.9kg/m2;
(3) No abnormal blood pressure (systolic blood pressure <120mmHg, diastolic blood pressure <80mmHg);
(4) Did not take any medicine for nearly 4 weeks;
(5) There is no major disease in the past;
(6) Subjects gave informed consent and signed informed consent.

Exclusion Criteria

(1) Patients with hypertension;
(2) Those with previous history of hyperlipidemia and cardiovascular and cerebrovascular diseases;
(3) Active ulcers and bleeding tendency, long-term use of anticoagulant, antiplatelet drugs;
(4) Those who are taking antihypertensive and lipid-lowering drugs;
(5) Those with severe heart, lung, liver and kidney dysfunction and nervous system diseases;
(6) Other diseases or mental illnesses that the investigator believes may limit efficacy evaluation or patient follow-up;
(7) Patients who have participated in other drug clinical trials in the past 4 weeks.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure;Renin;Angiotensin II;

Secondary Outcome Measures

Name	Time	Method
Fibrinogen;Triglyceride;Total cholesterol;Fasting blood sugar;Partial thromboplastin time;Thrombin time;Low density lipoprotein cholesterol;Prothrombin time;Transcriptomics;High density lipoprotein cholesterol;Platelet function test;Genomics;