Vitamin K-absorption From Dairy

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: vitamin K-rich dairy product

• Registration Number: NCT00931437
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-04
• Study First Submitted: 2009-06-30
• Study First Submitted QC: 2009-06-30
• Primary Completion: 2009-07
• Study First Posted: 2009-07-02
• Study Completion: 2009-11
• Status Verified: 2010-12
• Last Update Submitted: 2010-12-15
• Last Update Posted: 2010-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy men and women between 20 and 45 years old
• Subjects of normal body weight and height according to BMI < 30
• Subjects of Caucasian race
• Subject has given written consent to take part in the study

Exclusion Criteria

• Subjects with (a history of) metabolic or gastrointestinal disease
• Subjects presenting chronic degenerative and/or inflammatory disease
• Abuse of drugs and/or alcohol
• Subjects receiving corticoid treatment
• Subjects using oral anticoagulants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
vitamin K-rich dairy product	vitamin K-rich dairy product	one single intake of a dairy product containing several K-vitamins: phylloquinone, menaquinone-7,8,9-and 10.

Primary Outcome Measures

Name	Time	Method
serum vitamin K levels: phylloquinone, menaquinone-7,-8,-9,and -10	one single intake

Secondary Outcome Measures

Name	Time	Method
distribution of vitamin K-forms over lipoprotein fractions: triglyceride rich lipoprotein (TGRLP), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), high density lipoprotein (HDL) as well as the lipoprotein-free fraction (LPF)	one single intake

Trial Locations

Locations (1)

VitaK BV / University of Maastricht; 🇳🇱 Maastricht, Netherlands