The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children
Phase 3
Completed
- Conditions
- Malaria
- Interventions
- Dietary Supplement: Vitamin A , Zinc and MultivitaminDietary Supplement: Vitamin ADietary Supplement: Vitamin A and ZInc
- Registration Number
- NCT02878265
- Lead Sponsor
- University of Ghana
- Brief Summary
The aim of this study was to determine the effect of combining vitamin A (VA), zinc (Z) and multivitamins (MV- A, B1, B2, B6, B12, C, D and E) on malaria morbidity
- Detailed Description
A total of 542 children aged between 6-59 months received either: (i) VA (control) or (ii) VA \& Z (VAZ) or (iii) VA, Z \& MV (VAZM). VA was delivered as a single dose while MV and Z were delivered daily. Malaria cases were managed by community health workers, who used rapid diagnostic test to confirm infection prior to treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 547
Inclusion Criteria
- under 5years
- will stay in the community for 10years
Exclusion Criteria
- chronic diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vitamin A , Zinc and Multivitamin Vitamin A , Zinc and Multivitamin A single dose of 20,000IU Vitamin A , 10mg of elemental zinc each day and 0.5ml/kg multivitamin syrup for 5 months Vitamin A Vitamin A A single dose of 20,000IU Vitamin A for the whole study period Vitamin A and zinc Vitamin A and ZInc A single dose of 20,000IU Vitamin A and 10mg of elemental zinc each day for 5 months
- Primary Outcome Measures
Name Time Method Incidence of clinical malaria attacks Baseline and every month up to six months While taking the supplement, malaria incidence will be measured
- Secondary Outcome Measures
Name Time Method Incidence of diarrhea attacks Every month up to six months While taking the supplement, diarrhea incidence will be measured
Trial Locations
- Locations (1)
Amoako
🇬🇭Accra, Ghana