Effect of Ageing on Airway Remodeling

Not Applicable

Terminated

• Conditions: Aging
• Interventions: Other: EFR and TDM

• Registration Number: NCT01230879
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Detailed Description

Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Study Timeline

• Study Start: 2009-07-15
• Study First Submitted: 2010-08-04
• Study First Submitted QC: 2010-10-28
• Study First Posted: 2010-10-29
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-23
• Last Update Posted: 2021-11-30

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion Criteria

• Chronic cough
• Dyspnea
• Sinonasal or chest infection during enrollment
• Myocardial infarction.
• Current smoker or past smoker with more than 10 pack year intoxication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
71 - 80 years old	EFR and TDM	EFR and TDM
81 - 95 years old	EFR and TDM	EFR and TDM
60 - 70 years old	EFR and TDM	EFR and TDM

Primary Outcome Measures

Name	Time	Method
Bronchial wall thickness	1 day	Bronchial wall thickness and remodeling associated with aging

Trial Locations

Locations (1)

University Montpellier Hospital; 🇫🇷 Montpellier, France