Predicting and Understanding Depression Prevention Techniques: a mechanistic cross-over trial of mindfulness vs. fantasizing to reduce vulnerability for depression

niversity Medical Center Groningen0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

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•In order to be eligible to participate in this study, a participant must meet all the following criteria:
•-Participants should be between 18 and 60 years old. They should not exceed 60 years of age in order to avoid aging related pathology in information processing (Salthouse, 2010);
•-Participants should display normal intelligence (IQ>85, as assessed with the Dutch Adult Reading Test (DART; Schmand et al., 1991) and/or having finished an education on at least vocational level).
•In order to be eligible to participate in the patient group of the study, a patient participant must additionally meet all the following criteria:
•-Participating patients should be in (partial or complete) remission from an Major Depressive episode for more than two months, criteria defined by the Diagnostic Statistical Manual, version 5;
•-Patients should have experienced at least two depressive episodes, criteria defined by the Diagnostic Statistical Manual, version 5, experienced in past ten years;
•-Patients should score 21 or lower on the Inventory of Depressive Symptomatology (IDS-SR30), indicative of the absence of clinically relevant depressive symptoms (Rush et al., 2000).

•A potential participant who meets any of the following criteria will be excluded from participation in this study:
•-Participants with any current DSM-5 diagnoses as objectified with the SCID-I;
•-Daily use of anti-depressant medication, benzodiazepines, methylphenidate, beta blockers or other medication potentially influencing ICG/ECG currently or in the last four weeks;
•-Participants who recently (defined as their last episode, or as one year prior to inclusion in case the last episode was more than a year before inclusion) received the preventive cognitive therapy including the positive fantasizing technique and/or have recent experiences (defined as daily practice in mindfulness in the past two years for at least two weeks) with mindfulness, meditation or mindful yoga. This will be done to prevent overestimation of true effects of mindfulness and/or positive fantasizing;
•-Participants who participate in another clinical intervention study at the moment of inclusion in the study.
•A potential participant for the HC group who meets any of the following criteria will be excluded from participation of this study:
•-Presence of symptoms of depression according to the IDS-SR30 (score < 13);
•-Any life-time psychopathology of any disorder as objectified with the SCID-I.

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