Plasma, Urine and Tear Omics Changes Based on Protein and Metabonomics Technology in Different Diets and Screening of Healthy Diet Markers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Proteomics and metabolomics changes after diet intervention
研究概览
简要总结
The study plans to start in July 2021, and it is expected that 20 healthy people (aged 18-70 years old, BMI 18.5-40kg/m2) will carry out a 5-week intervention and follow-up. Participants will be enrolled in the group through the screening and plan to take regular diet, OGTT, high-fat diet, low-calorie diet and ketogenic diet within 5 weeks. The proteomics and metabolomics indicators of tear, plasma, and urine specimens will be measured at 5 time points at baseline, 30 minutes, 1 hour, 2 hours, and 3 hours for each diet. The correlation of proteomics and metabolomics indicators with classic laboratory parameters (BMI, HDL, LDL, cholesterol, triglyceride levels, and insulin resistance (HOMA-IR)) will be analyzed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals aged 20-70 years, with a body mass index (BMI) of 18.5-40 kg/m².
- •No known chronic medical conditions.
- •Willingness to comply with study requirements and adhere to the intervention protocol.
排除标准
- •Presence of significant medical conditions or chronic diseases.
- •Diagnosis of diabetes mellitus or prediabetes.
- •Triglyceride level ≥4 mmol/L.
- •Blood pressure ≥160/100 mmHg or presence of malignant hypertension.
- •History of an eating disorder.
- •Previous bariatric surgery.
- •Severe gastrointestinal diseases.
- •History of diarrhea within the past two weeks.
- •Special dietary requirements or known food allergies.
- •Pregnancy or breastfeeding.
结局指标
主要结局
Proteomics and metabolomics changes after diet intervention
时间窗: 5 weeks
Changes of plasma, urine, tear proteomics and metabolomics after diet intervention
次要结局
未报告次要终点