A study of the acute and chronic cognitive, neurocognitive and blood flow effects of polyphenols in middle aged volunteers.

Not Applicable

Completed

• Conditions: Cognitive function; Cardiovascular function; Neuro-cognitive function; Alternative and Complementary Medicine - Other alternative and complementary medicine; Cardiovascular - Normal development and function of the cardiovascular system; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12609000879268
• Lead Sponsor: Barry Callebaut

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-10-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

non smoker
- aged between 40 and 65 years
- no history of anxiety, depression, psychiatric disorders or epilepsy
- not taking any medication, herbal extracts, vitamin supplements or illicit drugs
- no health conditions that would effect food metabolism including the following: food allergies, kidney disease, liver disease and/or gastrointestinal diseases (e.g Irritable bowel syndrome, celiac disease, peptic ulcers)
- not pregnant or breast feeding.

Exclusion Criteria

- smoker
- history of anxiety, depression, psychiatric disorders or epilepsy
- taking any medication, herbal extracts, vitamin supplements or illicit drugs
- health conditions that would effect food metabolism including the following: food allergies, kidney disease, liver disease and/or gastrointestinal diseases (e.g Irritable bowel syndrome, peptic ulcers)
- pregnant or breast feeding.
- Free from epilepsy and have no history of epilepsy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiovascular function measured using Transcranial Doppler (TCD) ultrasound to measure blood flow in the middle cerebral artery and common corotid artery and the Sphygmocor (arterial stiffness) system[ACUTE: 2 hours post dose <br>CHRONIC: 4 weeks after consuming chocolate treatment each day for 4 weeks<br>CHRONIC/ACUTE: 2 hours post dose on second visit (4 weeks after consumption)];Cognitive performance measured using Cognitive Drug Research (CDR) computerised cognitive battery[ACUTE: 1 hour, 2.5 hours and 4 hours post dose<br><br>CHRONIC: 4 weeks after consuming chocolate treatment each day for 4 weeks<br><br>CHRONIC/ACUTE: 1 hour, 2.5 hours and 4 hours post dose on second visit (4 weeks after consumption)]

Secondary Outcome Measures

Name	Time	Method
euro-cognitive performance using Steady State Topography (SST)[CHRONIC: 4 weeks (after consuming chocolate treatment each day for 4 weeks)]