Cognitive outcome after Gamma Knife Radiosurgery in patients with brain metastases - Cognitive outcome after GKRS

Sint Elisabeth Ziekenhuis0 个研究点目标入组 101 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•* Contrast enhanced volumetric MRI showing 1-10 newly diagnosed BM with a total tumor volume * 30cc
•* Lesion > 3 mm from optic apparatus*
•* Patient age * 18 years*
•* Karnofsky Performance Status * 70, WHO performance status * 2*
•* Anticipated survival (independent of the BM) greater than 3 months
•Dutch healthy control subjects will be:
•* Sociodemographically similar to the patient group
•* In good health, with no current or past psychiatric, neurologic, or cognitive disorder, and mediation-use that interferes with cognitive function

•* No prior histologic confirmation of malignancy
•* Primary brain tumor, small cell lung cancer, lymphoma, leukemia, or meningeal disease
•* Progressive, symptomatic systemic disease without further treatment options
•* Prior brain radiation or surgical resection of BM
•* Additional history of a significant neurological or psychiatric disorder
•* Participation in a concurrent study in which neuropsychological testing and/or health-related QOL assessments are involved
•* Patients unable to complete test battery and/or study questionnaires due to any of the following reasons: lack of basic proficiency in Dutch, IQ below 85, severe aphasia, or paralysis

发起方

Sint Elisabeth Ziekenhuis