Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training

Phase 1

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Device: U-SMART

• Registration Number: NCT01628653
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

The purpose of this study is to examine feasibility and efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART) in the elderly individuals with mild cognitive impairment (MCI).

Detailed Description

The Spaced Retrieval-based Memory Advancement and Rehabilitation Training (SMART) which consisted of 24 one-hour face-to-face sessions (Lee, Park et al. 2009) was developed based on the spaced retrieval training (SRT), which was effective in improving memory retention span of very mild to mild Alzheimer's disease patients. The Ubiquitous SMART (U-SMART) by transforming the current SMART to a self-administered program using an application working on IPAD was developed, and was examined its feasibility and efficacy in the elderly individuals with mild cognitive impairment.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2011-06
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2012-06
• Study First Submitted: 2012-06-23
• Study First Submitted QC: 2012-06-23
• Last Update Submitted: 2012-06-23
• Study First Posted: 2012-06-27
• Last Update Posted: 2012-06-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Aged 55-90
• Educational level above 1 year and confirmed literacy
• Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment
• Clinical Dementia Rating (CDR) of 0 or 0.5

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Exclusion Criteria

• Diagnosed to dementia by DSM-IV
• Evidence of delirium, confusion
• Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus
• Evidence of severe cerebrovascular pathology
• History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity
• History of substance abuse or dependence such as alcohol
• Presence of depressive symptoms that could influence cognitive function
• Presence of medical comorbidities that could result in cognitive decline
• Use of medication that could influence cognitive function seriously

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
U-SMART	U-SMART	U-SMART (Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training)

Primary Outcome Measures

Name	Time	Method
the five-point Likert scales for satisfaction and compliance	after 4-weeks treatment	To evaluate the feasibility of the U-SMART, the five-point Likert scales for satisfaction and compliance were applied to all participants.
Word List Memory Test of the CERAD Neuropsychological Assessment Battery	after 4-weeks treatment	To evaluate the efficacy of the U-SMART, the Word List Memory Test (WLMT) of the CERAD neuropsychological assessment battery was applied to all participants.

Secondary Outcome Measures

Name	Time	Method
Mini-Mental State Examination (MMSE)	after 4-weeks treatment

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Gyeonggi, Korea, Republic of