The Effect of Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery: A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Neuroendocrine stress response
研究概览
简要总结
This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.
详细描述
Umbilical hernias of the abdomen are defined as a non-inguinal, non-hiatal defect in the fascia of the abdominal wall. Surgical stress response refers to the physiologic response to surgery and the hormonal and metabolic changes that follow it.
Fascial plane blocks are gaining attention for perioperative analgesia due to their efficacy and safety profiles. The external oblique and rectus abdominis plane (EXORA) block is an emerging technique that provides a sensory block to the anterolateral abdominal wall, potentially filling gaps left by other commonly used blocks, such as the quadratus lumborum (QLB) or erector spinae plane (ESP) blocks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged from 21 to 65 years.
- •Both sexes.
- •American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
- •Schedule for elective umbilical hernia surgery under general anesthesia.
排除标准
- •ASA Ⅲ or Ⅳ.
- •Patients with metabolic abnormalities, e.g., diabetes mellitus.
- •Patients receiving corticosteroids.
- •History of allergies to local anesthetics.
- •Bleeding or coagulation disorders.
- •Anatomical abnormalities.
- •Psychiatric and neurological disorders.
- •Complicated hernial defect (obstructed).
- •Patient refusal.
结局指标
主要结局
Neuroendocrine stress response
时间窗: 24 hours postoperatively
Neuroendocrine stress response will be measured by blood glucose level in adults undergoing umbilical hernia repair.
次要结局
- Serum cortisol level(24 hours postoperatively)
- Time of first rescue analgesia(24 hours postoperatively)
- Total intraoperative fentanyl consumption(Intraoperatively)
- Total morphine consumption(24 hours postoperatively)
- Degree of pain(24 hours postoperatively)
研究者
Mayada Hady Mahmoud Sokeer
Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Tanta University, Tanta, Egypt.
Tanta University