NCT02222883已完成不适用
Prevalence of BRCA in Patients With Primary or Platinum Sensitive Recurrent Ovarian Cancer.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 530
- 试验地点
- 19
- 主要终点
- Germline alterations in BRCA1/2 (yes/no) and other ovarian cancer predisposing genes (yes/no; if yes which)
研究概览
简要总结
The aim of this prospective registration and translational research study is to evaluate the praevalence of BRCA regarding germline and somatic mutations.
详细描述
Explorative analysis will be performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female ovarian cancer patients aged >= 18 years.
- •Women with first diagnosis of epithelial ovarian cancer OR women diagnosed with platinum-sensitive recurrent ovarian cancer.
- •Multiple platinum based prior therapies are allowed.
排除标准
- •Non-epithelial ovarian malignancy.
- •Platinum-resistant or refractory disease.
- •Paraffin embedded tumor samples not available.
结局指标
主要结局
Germline alterations in BRCA1/2 (yes/no) and other ovarian cancer predisposing genes (yes/no; if yes which)
时间窗: once per sample
次要结局
- Results of Immunohistochemistry in tumor samples(once per sample)
- Patient Survey for perspectives and satisfaction regarding testing and counseling(once after BRCA result is available)
- Determining the correlation of genetic alterations, cancer treatments, overall survival, progression-free survival and occurrence of new malignancies(once)
- Somatic alterations in BRCA1/2 (yes/no) and other ovarian cancer predisposing genes (yes/no; if yes which)(once per sample)
- BRCAness tumor phenotype in ovarian cancer (yes/no).(once per sample)
- Differences of tumor samples from primary and relapsed disease(once per sample for each stage of disease)
研究者
研究点 (19)
Loading locations...
相似试验
尚未招募
不适用
BRCA 1/2 Status as a Predictive Factor to Response to Platinum Based Chemotherapy in Cancer OvaryOvarian CancerNCT06304922Assiut University45
已完成
不适用
Prevalence of BRCA1 and BRCA2 Mutations in Ovarian Cancer Patients in the Gulf RegionOvarian CancerNCT03082976AstraZeneca108
已完成
不适用
Written Genetic Counseling and Mutation Analysis of BRCA1 and BRCA2 to Patients With Breast CancerHereditary Breast CancerNCT02557776Lund University542
已完成
不适用
FLABRA: Frontline Approach for BRCA Testing in OC Treatment naïve Population. A LATIN AMERICA Epidemiologic StudyOvarian CancerNCT02984423AstraZeneca471
已完成
不适用
Prevalence of BRCA in Patients with primary platinum sensitive recurrent ovarian cancerC56Malignant neoplasm of ovaryDRKS00006745AGO Research GmbH, AGO Study Group530