Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Change in Exhaled Inflammatory Mediator Levels
研究概览
简要总结
Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal subjects.
详细描述
Aim:
- To study the effect of low dose aspirin on exhaled breath inflammatory mediators
- To compare the change to that seen in diseased states such as asthma and Lymphangioleiomyomatosis (LAM)
We will interview healthy volunteers to confirm that they do not have any major underlying medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will collect breath condensate before and after two weeks of low dose over the counter enteric coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include bleeding, heart burn and allergic reaction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adults
排除标准
- •any underlying major medical conditions such as heart disease, hypertension, stroke, diabetes, bleeding disorders
研究组 & 干预措施
aspirin
Low dose daily aspirin in healthy volunteers for two weeks
干预措施: aspirin (Drug)
结局指标
主要结局
Change in Exhaled Inflammatory Mediator Levels
时间窗: baseline and 6 months
Descriptive statistics
次要结局
未报告次要终点
研究者
Elliot Israel, MD
Elliot Israel, MD
Brigham and Women's Hospital