Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects
- Registration Number
- NCT00898222
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal subjects.
- Detailed Description
Aim:
1. To study the effect of low dose aspirin on exhaled breath inflammatory mediators
2. To compare the change to that seen in diseased states such as asthma and Lymphangioleiomyomatosis (LAM)
We will interview healthy volunteers to confirm that they do not have any major underlying medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will collect breath condensate before and after two weeks of low dose over the counter enteric coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include bleeding, heart burn and allergic reaction.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 4
- healthy adults
- any underlying major medical conditions such as heart disease, hypertension, stroke, diabetes, bleeding disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description aspirin aspirin Low dose daily aspirin in healthy volunteers for two weeks
- Primary Outcome Measures
Name Time Method Change in Exhaled Inflammatory Mediator Levels baseline and 6 months Descriptive statistics
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Asthma Research Center, Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States