Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
- Conditions
- Syncope, Vasovagal, Neurally-Mediated
- Registration Number
- NCT06697145
- Lead Sponsor
- Wroclaw Medical University
- Brief Summary
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin. Effectiveness of the procedure is satisfactory, however, in some cases there is a possibility of the re-growth of previously ablated tissue. We aim to investigate whether this process could be traced by measurement of various physiological parameters related to heart rate reactivity. Additionally we intend to reveal whether changes in those parameters over time could influence clinical effeciveness of the procedure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
- signed informed consent
- sinus rhythm
- clinical indications for cardioneuroablation for the treatment of vagally-mediated syncope
- pregnancy
- known atropine hypersensitivity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Change in degree of parasympathetic denervation (%) 12 months
- Secondary Outcome Measures
Name Time Method Change in cardiac barosensitivity (ms/mmHg) 12 months Change in hypoxic heart rate response (beats/min SpO2) 12 months Time to recurrence of syncopal event (days 12 months Change in heart rate variability (ms) 12 months Change in heart rate (beats/min) 12 months
Related Research Topics
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Trial Locations
- Locations (1)
Wroclaw Medical University
🇵🇱Wroclaw, Dolnoslaskie, Poland