The Effect of Multiple Injection of Platlet-rich Plasma in Chronic Patellar Tendinopathy
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Change from baseline Victorian Institute of Sport Assessment (VISA-P) score to 36 weeks
研究概览
简要总结
According to previous studies, the effect of PRP to patellar tendinopathy could last longer. However, the type, concentration, time and frequent of injection are still debated。 This study is to understand the effect of multiple injection of platlet-rich plasma in chronic patellar tendinopathy and to analyze the relation between efficacy of PRP and the growth factor in PRP.
详细描述
Patellar tendinopathy, also known as jumper's knee，is clinically common characterised by anterior knee pain, activity-related pain、local tenderness over inferior pole of patella. The discomfort can result in decreasing athletic performance and be one of the most challenge for sports medicine doctor.
The patellar tendon suffer from repetitive microtrauma，result in reactive patellar tendinopathy. The overload tendon combining with risk factors of patellar tendinopathy will not recover timely and progress to chronic patellar tendinopathy. Hence, to reverse the progression is our aim.
According to previous studies, several nonsurgical treatment options have been proposed such as medication, eccentric exercise, corticosteroid injection, shockwave and platelet-rich plasma (PRP). Among all the options, the effect of PRP could last longer. However, the type, concentration, time and frequent of injection are still debated。Moreover, there is no study about the relationship between efficacy and the ratio and concentration of growth factor in the PRP.
The aim of this study is to understand (1) The effect of multiple injection of platlet-rich plasma in chronic patellar tendinopathy. (2) The effect of leukocyte-rich PRP in chronic patellar tendinopathy (3) Analyze the relation between efficacy of PRP and the growth factor in PRP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic patellar tendinopathy
排除标准
- •Corticosteroid injections within 12 months
- •Previous knee surgery
- •Any confounding diagnosis to the knee joint
- •Rheumatoid arthritis
- •Infections of knee joint
- •NSAIDs in the 10 days before the procedure
结局指标
主要结局
Change from baseline Victorian Institute of Sport Assessment (VISA-P) score to 36 weeks
时间窗: 36 weeks
Clinical evaluation for patellar tendinopathy minimum score: 0(worse outcome) maximum score: 100(better outcome)
Change from baseline modified Blazina Scale to 36 weeks
时间窗: 36 weeks
Clinical evaluation for patellar tendinopathy Stage 0 - No pain Stage 1 - Pain only after intense sports activity; no undue functional impairment Stage 2 - Pain at the beginning and after sports activity; still able to perform at a satisfactory level Stage 3 - Pain during sports activity; increasing difficulty in performing at a satisfactory level Stage 4 - Pain during sports activity; unable to participate in sport at a satisfactory level Stage 5 - Pain during daily activity; unable to participate in sport at any level
Change from baseline thickness of patellar tendon to 36 weeks
时间窗: 36 weeks
Sonographic evaluation for patellar tendinopathy to measure the thickness of proximal patellar tendon.
Change from baseline Visual analogue score(VAS) to 36 weeks
时间窗: 36 weeks
evaluation for pain(minimal score:0, maximal score:10)
次要结局
- Correlation between Platlet derived growth factor (PDGF) and VISA-P score(36 weeks)
- Correlation between Epithelial growth factor (EGF) and VISA-P score(36 weeks)
- Change from baseline Victorian Institute of Sport Assessment (VISA) score to 104 weeks(104 weeks)
- Correlation between Transforming growth factor beta 1 (TGF beta 1) and VISA-P score(36 weeks)