JPRN-UMIN000003219已完成未知
Pilot study of preoperative chemotherapy of XELOX+ Bevacizumab in patients with locally-advanced lower rectal cancer - Pilot study of the preoperative chemotherapy of XELOX+ Bevacizumab in Patients with locally-advanced lower rectal cancer
Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group0 个研究点目标入组 20 人开始时间: 2010年2月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 75years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1)With malignant coelomic fluid. (2)With distant metastases (3)Multiple primary cancer within 5 years (4)With arterial thromboembolism, e.g. cerebrovascular disease (5)Any surgical treatments including skin-open biopsy, surgery of trauma and other more intensive surgery within 4 weeks or aspiration biopsy within one week. (6)Administering antithrombotic drug within 10 days. (7)Need to administrate or having anti-platelets therapy (including aspirin and NSAIDS) (8)Bleeding tendency or coagulation disorder (INR 1.5 and over) (9)Symptom of colorectal obstruction (10)Uncontrolled complication of peptic ulcer (11)Current or previous (within the last 1 year) history of GI perforation (12)Serious renal complications or having 2+ uric protein (13)Uncontrolled hypertension (14)Symptomatic or asymptomatic but treated heart disease (15)History of the serious hypersensitivity for Fluorouracil, platinum compound and levofolinate calcium (16)History of adverse events related to DPD loss (17)Uncontrolled Diarrhea (18)Peripheral neuropathy (Grade1<=) (19)Uncontrolled infection (20)Pregnant women, possibly pregnant women, wishing to become pregnant, and nursing mothers. (21)No intention to practice birth control (22)Previously treated with bevacizumab or oxaliplatin (23)Other conditions not suitable for this study
研究者
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