NCT01788670已完成1 期
Hydroxytyrosol as an Endogenous and Natural Antioxidant: Modulation by Alcohol Intake. Substudy 1. Evaluating the Relevance of the Ethanol Dose in the Generation of Endogenous Hydroxytyrosol (DOPET).
Parc de Salut Mar2 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2009年5月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Hydroxytyrosol biological fluids concentrations
研究概览
简要总结
Health benefits for humans derived from low dose intake of ethanol could partially be explained by its interaction with dopamine (DA) oxidative metabolism. Ethanol is expected to induce an increase in the formation of a DA minor metabolite: DOPET (hydroxytyrosol). Hydroxytyrosol is one of the most potent antioxidants present in Mediterranean Diet. The study is aimed at establishing the contribution of ethanol on hydroxytyrosol formation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Clinical history and physical examination demonstrating no organic or psychiatric disorders.
- •The ECG and general blood and urine laboratory tests performed before the study should be within normal ranges. Minor or occasional changes from normal ranges are accepted if, in the investigator's opinion, considering the current state of the art, they are not clinically significant, are not life-threatening for the subjects and do not interfere with the product assessment. These changes and their non-relevance will be justified in writing specifically.
- •The body mass index (BMI=weigh/height2) will range from 19 to 27 kg/m2, and the weight from 50 to 110 kg.
- •Understanding and accepting the study procedures and signing the informed consent.
排除标准
- •Not meeting the inclusion criteria.
- •History or clinical evidence of alcoholism, drug abuse, or regular use of psychoactive drugs.
- •Having suffered any organic disease or major surgery in the three months prior to the study start.
- •History of psychiatric disorders.
- •Smokers of more than 20 cigarettes per day.
- •Taking more than 30 g of alcohol a day
- •Regular use of any drug in the month prior to the study sessions.The treatment with single or limited doses of symptomatic medicinal products in the week prior to the study sessions will not be a reason for exclusion if it is calculated that it has been cleared completely the day of the experimental session.
- •Blood donation 8 weeks before or participation in other clinical trials with drugs in the previous 12 weeks.
- •Subjects with intolerance or adverse reactions to ethanol
- •History or clinical evidence of gastrointestinal, liver, renal or other disorders which may lead to suspecting a disorder in drug absorption, distribution, metabolism or excretion, or that suggest gastrointestinal irritation due to drugs.
- •Subjects unable to understand the nature, consequences of the study and the procedures requested to be followed.
- •Subjects with positive serology to Hepatitis B, C or HIV.
- •To be eligible, the subjects must agree to follow a diet free from ethanol and olive oil in the 72 hours prior to the start of each session and until the end of the study.
结局指标
主要结局
Hydroxytyrosol biological fluids concentrations
时间窗: 0-24h after administration
Hydroxytyrosol concentrations in plasma and urine
次要结局
- Subjective drunkenness(0-6h after administration)
- Vital signs(0-6h after administration)
- Ethanol concentration(0-6h after administration)
- Ethanol metabolites concentrations(0-24h after administration)
- Dopamine metabolites concentrations(0-24h after administration)
研究者
研究点 (2)
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